A Series of Analogues to the AT2 R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode-Reference-Cited by-同舟云学术

A Series of Analogues to the AT2 R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Published:2019-01 Issue:1 Volume:8 Page:114-125
ISSN:2191-1363
Container-title:ChemistryOpen
language:en
Short-container-title:ChemistryOpen

Author:

Isaksson Rebecka¹^ORCID,Lindman Jens¹^ORCID,Wannberg Johan²^ORCID,Sallander Jessica³^ORCID,Backlund Maria⁴^ORCID,Baraldi Dhaniel⁵^ORCID,Widdop Robert⁵^ORCID,Hallberg Mathias⁶^ORCID,Åqvist Johan³^ORCID,Gutierrez de Teran Hugo³^ORCID,Gising Johan¹^ORCID,Larhed Mats¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry; Uppsala University; SE-751 23 Uppsala SWEDEN

2. SciLifeLab Drug Discovery & Development Platform, Medicinal Chemistry - Lead Identification, Department of Medicinal Chemistry; Uppsala University; SE-751 23 Uppsala SWEDEN

3. Department of Cell and Molecular Biology; Uppsala University; SE-751 23 Uppsala SWEDEN

4. SciLifeLab Drug Discovery & Development Platform, ADME of Therapeutics, Department of Pharmacy; Uppsala University; SE-751 23 Uppsala SWEDEN

5. Department of Pharmacology; Monash University; Clayton, Victoria 3800 AUSTRALIA

6. The Beijer Laboratory, Department of Pharmaceutical Biosciences; Uppsala University; SE-751 24 Uppsala SWEDEN

Funder

SciLifeLab Drug Discovery and Development Platform

Swedish National Infrastructure for Computing

Märta Beijer Foundation

Swedish Research Council

Publisher

Wiley

Subject

General Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/open.201800282/fullpdf

Reference58 articles.

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4. AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function

5. Perspective: A tale of two receptors

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