Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor-Reference-Cited by-同舟云学术

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor

Published:2017-06-05 Issue:4 Volume:6 Page:501-505
ISSN:2191-1363
Container-title:ChemistryOpen
language:en
Short-container-title:ChemistryOpen

Author:

Jones Ben J.¹^ORCID,Scopelliti Rosario²^ORCID,Tomas Alejandra³^ORCID,Bloom Stephen R.¹^ORCID,Hodson David J.⁴⁵^ORCID,Broichhagen Johannes²⁶^ORCID

Affiliation:

1. Imperial College London, Section of Investigative Medicine; Division of Diabetes, Endocrinology and Metabolism; London W12 0NN UK

2. École Polytechnique Fédérale de Lausanne; ISIC SB, Laboratory of Protein Engineering; Av. Forel 2 1015 Lausanne Switzerland

3. Imperial College London; Section of Cell Biology and Functional Genomics, Department of Medicine; London W12 0NN UK

4. Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE); University of Birmingham; Birmingham B15 2TT UK

5. Centre for Endocrinology, Diabetes and Metabolism; Birmingham Health Partners; Birmingham B15 2TH UK

6. Current address: Max Planck Institute for Medical Research; Department of Chemical Biology; Jahnstraße 29 69120 Heidelberg Germany

Funder

Medical Research Council

Biotechnology and Biological Sciences Research Council

National Institute for Health Research

Integrative Mammalian Biology Capacity Building Award

EuroCHIP Grant

NIHR Imperial Biomedical Research Centre Funding Scheme

Diabetes UK Early-Career Small Grant

Diabetes UK R.D. Lawrence

European Foundation for the Study of Diabetes

Wellcome Trust

European Research Council

H2020 Marie Skłodowska-Curie Actions

Publisher

Wiley

Subject

General Chemistry

Reference32 articles.

1. Structure-Function of the G Protein–Coupled Receptor Superfamily

2. Allosteric Modulation of Endogenous Metabolites as an Avenue for Drug Discovery

3. Minireview: Signal Bias, Allosterism, and Polymorphic Variation at the GLP-1R: Implications for Drug Discovery

4. Allosteric Optical Control of a Class B G-Protein-Coupled Receptor

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