Dose-dependent pharmacokinetics and tentative identification of urine metabolites from an isosteviol derivative with anti-hepatitis B activity in rats

Author:

Kachingwe Baxter Hepburn12,Wang Li-Hsuan1,Uang Yow-Shieng34,Huang Tsurng-Juhn5,Lin Shwu-Jiuan16ORCID

Affiliation:

1. School of Pharmacy; Taipei Medical University; Taipei Taiwan

2. Department of Pharmacy, College of Medicine; University of Malawi; Blantyre Malawi

3. Graduate Institute of Pharmacognosy, College of Pharmacy; Taipei Medical University; Taipei Taiwan

4. Rosetta Pharmamate Co. Ltd; Taipei Taiwan

5. School of Medicine; China Medical University; Taichung Taiwan

6. PhD Program in Clinical Drug Development of Chinese Herbs Medicine, College of Pharmacy; Taipei Medical University; Taipei Taiwan

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference36 articles.

1. Microbial Transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products;Akihisa;Journal of Natural Products,2004

2. Studies of isosteviol diterpenoid derivatives by mass spectrometry: II. Fragmentation of isosteviol esters under the electronic impact;Babaev;Russian Journal of General Chemistry,2011

3. Determination of isosteviol by LC-MS/MS and its application for evaluation of pharmacokinetics of isosteviol in rat;Bazargan;DARU Journal of Pharmaceutical Sciences,2007

4. Hepatitis B virus replication;Beck;World Journal of Gastroenterology,2007

5. Steviol glycosides: Chemical diversity, metabolism, and function;Ceunen;Journal of Natural Products,2013

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