Inter‐individual and inter‐regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors-Reference-Cited by-同舟云学术

Inter‐individual and inter‐regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors

Published:2020-08-26 Issue:5 Volume:8 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol. Res. Perspect.

Author:

Li Albert P.¹^ORCID,Ho Ming‐Chih D.¹,Alam Novera¹,Mitchell Walter¹,Wong Susan²,Yan Zhengyin²,Kenny Jane R.²,E. C. A. Hop Cornelis²

Affiliation:

1. In Vitro ADMET Laboratories, Inc. Columbia MD USA

2. Genentech Inc. South San Francisco CA USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.645

Reference84 articles.

1. Midazolam Pharmacokinetics in Morbidly Obese Patients Following Semi-Simultaneous Oral and Intravenous Administration: A Comparison with Healthy Volunteers

2. First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates

3. Sex-Dependent Differences in Cytochrome P450 3A Activity as Assessed by Midazolam Disposition in Humans: A Meta-Analysis

4. Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

5. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

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