Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits-Reference-Cited by-同舟云学术

Ablation of oligodendrogenesis in adult mice alters brain microstructure and activity independently of behavioral deficits

Published:2024-07-09 Issue:10 Volume:72 Page:1728-1745
ISSN:0894-1491
Container-title:Glia
language:en
Short-container-title:Glia

Author:

Kaller Malte S.¹^ORCID,Lazari Alberto¹^ORCID,Feng Yingshi¹,van der Toorn Annette²,Rühling Sebastian¹³,Thomas Christopher W.⁴^ORCID,Shimizu Takahiro⁵^ORCID,Bannerman David⁶^ORCID,Vyazovskiy Vladyslav⁴⁷⁸^ORCID,Richardson William D.⁵^ORCID,Sampaio‐Baptista Cassandra¹⁹^ORCID,Johansen‐Berg Heidi¹^ORCID

Affiliation:

1. Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK

2. Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences University Medical Center Utrecht & Utrecht University Utrecht The Netherlands

3. Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar Technical University of Munich Munich Germany

4. Department of Physiology, Anatomy and Genetics University of Oxford Oxford UK

5. The Wolfson Institute for Biomedical Research University College London London UK

6. Department of Experimental Psychology University of Oxford Oxford UK

7. Sir Jules Thorn Sleep and Circadian Neuroscience Institute University of Oxford Oxford UK

8. The Kavli Institute for Nanoscience Discovery University of Oxford Oxford UK

9. School of Psychology and Neuroscience University of Glasgow Glasgow UK

Abstract

AbstractOligodendrocytes continue to differentiate from their precursor cells even in adulthood, a process that can be modulated by neuronal activity and experience. Previous work has indicated that conditional ablation of oligodendrogenesis in adult mice leads to learning and memory deficits in a range of behavioral tasks. The current study replicated and re‐evaluated evidence for a role of oligodendrogenesis in motor learning, using a complex running wheel task. Further, we found that ablating oligodendrogenesis alters brain microstructure (ex vivo MRI) and brain activity (in vivo EEG) independent of experience with the task. This suggests a role for adult oligodendrocyte formation in the maintenance of brain function and indicates that task‐independent changes due to oligodendrogenesis ablation need to be considered when interpreting learning and memory deficits in this model.

Funder

Wellcome Trust

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/glia.24576

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