Epitopes of Naturally Acquired and Vaccine‐Induced Anti‐Ebola Virus Glycoprotein Antibodies in Single Amino Acid Resolution

Author:

Heidepriem Jasmin1ORCID,Krähling Verena23,Dahlke Christine456,Wolf Timo7,Klein Florian8910,Addo Marylyn M.456,Becker Stephan23,Loeffler Felix F.1

Affiliation:

1. Max Planck Institute of Colloids and Interfaces Department of Biomolecular Systems Potsdam 14476 Germany

2. Institute of Virology, Faculty of Medicine Philipps University Marburg Marburg 35043 Germany

3. German Center for Infection Research partner site Gießen‐Marburg‐Langen Marburg 35043 Germany

4. Division of Infectious Diseases, First Department of Medicine University Medical Center Hamburg‐Eppendorf Hamburg 20246 Germany

5. Department of Clinical Immunology of Infectious Diseases Bernhard Nocht Institute for Tropical Medicine Hamburg 20359 Germany

6. German Center for Infection Research Partner Site Hamburg‐Lübeck‐Borstel‐Riems Hamburg 20359 Germany

7. Department of Medicine, Infectious Diseases Unit Goethe University Hospital Frankfurt 60590 Germany

8. Laboratory of Experimental Immunology Institute of Virology University of Cologne Faculty of Medicine and University Hospital of Cologne Cologne 50931 Germany

9. Center for Molecular Medicine Cologne (CMMC) University of Cologne Faculty of Medicine Cologne 50931 Germany

10. German Center for Infection Research partner site Bonn‐Cologne Cologne 50931 Germany

Funder

Bundesministerium für Gesundheit

Bundesministerium für Bildung und Forschung

Deutsches Zentrum für Infektionsforschung

Wellcome Trust

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Reference45 articles.

1. World Health Organization Ebola Virus Disease https://www.who.int/news-room/fact-sheets/detail/ebola-virus-disease(accessed: December 2019).

2. World Health Organization Ebola Virus Disease–Democratic Republic of the Congo https://www.who.int/csr/don/14-november-2019-ebola-drc/en/(accessed: December 2019).

3. A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection

4. Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

5. Safety, tolerability, pharmacokinetics, and immunogenicity of the therapeutic monoclonal antibody mAb114 targeting Ebola virus glycoprotein (VRC 608): an open-label phase 1 study

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