Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost‐effective method for expression of complex molecules-Reference-Cited by-同舟云学术

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Concurrent transfection of randomized transgene configurations into targeted integration CHO host is an advantageous and cost‐effective method for expression of complex molecules

Published:2020-12-30 Issue:4 Volume:16 Page:2000230
ISSN:1860-6768
Container-title:Biotechnology Journal
language:en
Short-container-title:Biotechnol. J.

Author:

Dong Emily¹,Lam Cynthia¹,Tang Danming¹,Louie Salina¹,Yim Mandy¹,Williams Ambrose J.²,Sawyer William³,Yip Shirley¹,Carver Joseph¹,AlBarakat Ali¹,Tsukuda Joni¹,Snedecor Brad¹,Misaghi Shahram¹^ORCID

Affiliation:

1. Cell Culture and Bioprocess Operations Department Genentech, Inc. 1 DNA Way South San Francisco California USA

2. Purification Development Department Genentech, Inc. 1 DNA Way South San Francisco California USA

3. Biochemical and Cellular Pharmacology Department Genentech, Inc. 1 DNA Way South San Francisco California USA

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.202000230

Reference23 articles.

1. Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

2. Introduction to current and future protein therapeutics: A protein engineering perspective

3. Production of recombinant protein therapeutics in cultivated mammalian cells

4. Biopharmaceutical benchmarks 2014

5. Strategies and Considerations for Improving Expression of “Difficult to Express” Proteins in CHO Cells

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Gene copy number, gene configuration and LC/HC mRNA ratio impact on antibody productivity and product quality in targeted integration CHO cell lines;Biotechnology Progress;2024-02-06

2. The impact of expression vector position on transgene transcription allows for rational expression vector design in a targeted integration system;Biotechnology Journal;2023-06-09

3. Reshaping cell line development and CMC strategy for fast responses to pandemic outbreak;Biotechnology Progress;2021-07-19

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