Comparison of mechanistic and hybrid modeling approaches for characterization of a CHO cultivation process: Requirements, pitfalls and solution paths
Author:
Affiliation:
1. Novasign GmbH Vienna Austria
2. Institute of Bioprocess and Biosystems Engineering Hamburg University of Technology Hamburg Germany
Funder
Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
Publisher
Wiley
Subject
Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/biot.202200381
Reference40 articles.
1. QbD/PAT for bioprocessing: moving from theory to implementation
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5. Model uncertainty-based evaluation of process strategies during scale-up of biopharmaceutical processes
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