The expression pattern of cytokeratin 6a in epithelial cells of different origin in dermo‐epidermal skin substitutes in vivo

Author:

Michalak‐Micka Katarzyna12ORCID,Tenini Celina12,Böttcher‐Haberzeth Sophie123,Mazzone Luca245,Pontiggia Luca12ORCID,Klar Agnes S.12ORCID,Moehrlen Ueli2345ORCID,Biedermann Thomas123ORCID

Affiliation:

1. Tissue Biology Research Unit Department of Surgery University Children's Hospital Zurich Zurich Switzerland

2. Children's Research Center (CRC) University Children's Hospital Zurich Zurich Switzerland

3. University of Zurich Zurich Switzerland

4. Spina Bifida Center University Children's Hospital Zurich Zurich Switzerland

5. The Zurich Center for Fetal Diagnosis and Therapy University of Zurich Zurich Switzerland

Abstract

AbstractKeratinocytes are the predominant cell type of skin epidermis. Through the programmed process of differentiation, they form a cornified envelope that provides a physical protective barrier against harmful external environment. Keratins are major structural proteins of keratinocytes that together with actin filaments and microtubules form the cytoskeleton of these cells. In this study, we examined the expression pattern and distribution of cytokeratin 6a (CK6a) in healthy human skin samples of different body locations, in fetal and scar skin samples, as well as in dermo‐epidermal skin substitutes (DESSs). We observed that CK6a expression is significantly upregulated in fetal skin and scar tissue as well as in skin grafts after short‐term transplantation. Importantly, the abundance of CK6a corresponds directly to the expression pattern of wound healing marker CK16. We postulate that CK6a is a useful marker to accurately evaluate the homeostatic state of DESSs.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Olga Mayenfisch Stiftung

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Effects of keratin6/16 heterodimer on diabetic wound healing treatment with topical metformin;Frontiers in Life Sciences and Related Technologies;2024-04-30

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