Advancing Raman model calibration for perfusion bioprocesses using spiked harvest libraries

Author:

Romann Patrick12ORCID,Kolar Jakub13,Tobler Daniela1,Herwig Christoph2ORCID,Bielser Jean‐Marc4,Villiger Thomas K.1ORCID

Affiliation:

1. Institute for Pharma Technology, School of Life Sciences University of Applied Sciences and Arts Northwestern Switzerland Muttenz Switzerland

2. Research Division Biochemical Engineering, Institute of Chemical Environmental and Bioscience Engineering Vienna University of Technology Vienna Austria

3. University of Chemistry and Technology Prague Prague Czechia

4. Biotech Process Sciences Merck Serono SA (an affiliate of Merck KGaA, Darmstadt, Germany) Corsier‐sur‐Vevey Switzerland

Publisher

Wiley

Subject

Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine

Reference31 articles.

1. ICH. (2009).ICH Harmonised Tripartite Guideline: Pharmaceutical Development Q8(R2). Retrieved February 2022 fromhttp://www.ich.org/

2. ICH. (2011).ICH Harmonised Tripartite Guideline: Development and Manufacture of Drug Substances (Chemical Entities and Biotechnological/Biological Entities) Q11. Retrieved February 2022 fromhttp://www.ich.org/

3. Noninvasive, On-Line Monitoring of the Biotransformation by Yeast of Glucose to Ethanol Using Dispersive Raman Spectroscopy and Chemometrics

4. Perfusion mammalian cell culture for recombinant protein manufacturing – A critical review

5. Real-time bioprocess monitoring

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