Prognostic impact of the hemoglobin–albumin–lymphocyte–platelet score in patients with oral cavity cancer undergoing surgery-Reference-Cited by-同舟云学术

Prognostic impact of the hemoglobin–albumin–lymphocyte–platelet score in patients with oral cavity cancer undergoing surgery

Published:2023-04-20 Issue:6 Volume:45 Page:1558-1571
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Fang Ku‐Hao¹²,Lai Chia‐Hsuan²³,Hsu Cheng‐Ming²⁴,Liao Chun‐Ta¹²,Kang Chung‐Jan¹²,Lee Yi‐Chan²⁵^ORCID,Huang Ethan I.²⁴,Chang Geng‐He²⁴,Tsai Ming‐Shao²⁴,Tsai Yao‐Te²⁴^ORCID

Affiliation:

1. Department of Otorhinolaryngology – Head and Neck Surgery Chang Gung Memorial Hospital Taoyuan Taiwan

2. College of Medicine Chang Gung University Taoyuan Taiwan

3. Department of Radiation Oncology Chang Gung Memorial Hospital Chiayi Taiwan

4. Department of Otorhinolaryngology – Head and Neck Surgery Chang Gung Memorial Hospital Chiayi Taiwan

5. Department of Otorhinolaryngology – Head and Neck Surgery Chang Gung Memorial Hospital Keelung Taiwan

Abstract

AbstractBackgroundWe aimed to probe the hemoglobin–albumin–lymphocyte–platelet (HALP) score's prognostic value in oral cavity squamous cell carcinoma (OSCC).MethodsMedical data of 350 patients with primary operated OSCC were retrospectively reviewed. We derived the optimal HALP cutoff by executing receiver operating characteristic curve analysis, and patients were then grouped based on this cutoff value. Cox proportional hazards model were used to discover survival outcome‐associated factors.ResultsWe derived the optimal HALP cutoff as 35.4. A low HALP score (<35.4) predicted poorer overall and disease‐free survival (hazard ratio: 2.29 and 1.92, respectively; both p < 0.001) and was significantly associated with OSCC aggressiveness. We established a HALP‐based nomogram that accurately predicted overall survival (concordance index: 0.784).ConclusionThe HALP score may be a useful prognostic biomarker in patients with OSCC undergoing surgery, and the HALP‐based nomogram can be a promising prognostic tool in clinical setting.

Funder

Chang Gung Medical Foundation

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27372

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