Imaging the dynamics and microstructure of fibrin clot polymerization in cardiac surgical patients using spectrally encoded confocal microscopy

Author:

Tshikudi Diane M.1ORCID,Simandoux Olivier1,Kang Dongkyun12,Van Cott Elizabeth M.3ORCID,Andrawes Michael N.4,Yelin Dvir5,Nadkarni Seemantini K.1

Affiliation:

1. Wellman Center for Photomedicine, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

2. College of Optical Sciences and Department of Biomedical Engineering University of Arizona Tucson Arizona USA

3. Department of Pathology, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

4. Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

5. Faculty of Biomedical Engineering Technion—Israel Institute of Technology Haifa Israel

Funder

Air Force Office of Scientific Research

National Institutes of Health

Publisher

Wiley

Subject

Hematology

Reference35 articles.

1. Monitoring of hemostasis in cardiac surgical patients: impact of point-of-care testing on blood loss and transfusion outcomes

2. Bleeding and management of coagulopathy

3. Gel point and fractal microstructure of incipient blood clots are significant new markers of hemostasis for healthy and anticoagulated blood;Evans PA;Thromb Haemost.,2010

4. Fibrin clots obtained from plasma containing heparin show a higher sensitivity to t-PA-induced lysis

5. Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA;Kalathottukaren MT;Thromb Haemost.,2018

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