Evaluation of the Effects of Repeat‐Dose Dabrafenib on the Single‐Dose Pharmacokinetics of Rosuvastatin (OATP1B1/1B3 Substrate) and Midazolam (CYP3A4 Substrate)-Reference-Cited by-同舟云学术

Evaluation of the Effects of Repeat‐Dose Dabrafenib on the Single‐Dose Pharmacokinetics of Rosuvastatin (OATP1B1/1B3 Substrate) and Midazolam (CYP3A4 Substrate)

Published:2021-05 Issue:9 Volume:10 Page:1054-1063
ISSN:2160-763X
Container-title:Clinical Pharmacology in Drug Development
language:en
Short-container-title:Clinical Pharmacology in Drug Development

Author:

Nebot Noelia¹,Won Christina S.²,Moreno Victor³,Muñoz‐Couselo Eva⁴,Lee Dung‐Yang¹,Gasal Eduard¹,Bouillaud Emmanuel⁵

Affiliation:

1. Novartis Pharmaceuticals Corporation East Hanover New Jersey USA

2. Novartis Institutes for BioMedical Research East Hanover New Jersey USA

3. START Madrid‐FJD Hospital Universitario Fundación Jiménez Díaz Madrid Spain

4. VHIO – Vall d'Hebron Institute of Oncology Vall d'Hebron University Hospital Barcelona Spain

5. Novartis Pharma AG Basel Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.937

Reference31 articles.

1. Effects of particle size, food, and capsule shell composition on the oral bioavailability of dabrafenib, a BRAF inhibitor, in patients with BRAF mutation-positive tumors

2. Concomitant Oral and Intravenous Pharmacokinetics of Dabrafenib, a BRAF Inhibitor, in Patients with BRAF V600 Mutation-Positive Solid Tumors

3. Metabolism and Disposition of Oral Dabrafenib in Cancer Patients: Proposed Participation of Aryl Nitrogen in Carbon-Carbon Bond Cleavage via Decarboxylation following Enzymatic Oxidation

4. The Metabolic Drug-Drug Interaction Profile of Dabrafenib: In Vitro Investigations and Quantitative Extrapolation of the P450-Mediated DDI Risk

5. Population pharmacokinetics of dabrafenib, a BRAF inhibitor: Effect of dose, time, covariates, and relationship with its metabolites

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