Affiliation:
1. Huzhou Central Hospital Affiliated Central Hospital Huzhou Universityy Huzhou Zhejiang Province China
2. Huzhou Central Hospital Fifth Affiliated Clinical Medical College of Zhejiang Chinese Medical University Huzhou Zhejiang Province China
3. Key Laboratory of Multiomics Research and Clinical Transformation of Digestive Cancer of Huzhou Huzhou Zhejiang Province China
Abstract
AbstractIn recent years, bacteria have gained considerable attention as a promising drug carrier that is critical in improving the effectiveness and reducing the side effects of anti‐tumor drugs. Drug carriers can be utilised in various forms, including magnetotactic bacteria, bacterial biohybrids, minicells, bacterial ghosts and bacterial spores. Additionally, functionalised and engineered bacteria obtained through gene engineering and surface modification could provide enhanced capabilities for drug delivery. This review summarises the current studies on bacteria‐based drug delivery systems for anti‐tumor therapy and discusses the prospects and challenges of bacteria as drug carriers. Furthermore, our findings aim to provide new directions and guidance for the research on bacteria‐based drug systems.
Funder
Natural Science Foundation of Zhejiang Province