Affiliation:
1. Division of Translational Oncoimmunology Aichi Cancer Center Research Institute Nagoya Japan
2. Department of Head and Neck Surgery Aichi Cancer Center Hospital Nagoya Japan
3. Department of Pathology and Molecular Diagnostics Aichi Cancer Center Hospital Nagoya Japan
4. Division of Cancer Immunogenomics Nagoya University Graduate School of Medicine Nagoya Japan
Abstract
AbstractBackgroundNear‐infrared photoimmunotherapy (NIR‐PIT) for head and neck cancer is a recently developed therapy. However, there is limited data on patients receiving NIR‐PIT in real clinical settings.MethodsSeven NIR‐PIT sessions were administered to five patients with head and neck squamous cell carcinoma (HNSCC). Serum damage‐associated molecular patterns (DAMPs) (HMGB1 and Hsp70 levels), and cytokine and chemokine production, were compared before and after NIR‐PIT.ResultsThe serum concentration of HMGB1 increased after NIR‐PIT (p = 0.031, Wilcoxon test) in all patients except one who did not achieve a clinical response. Chemokines MIP‐1α (CCL3) and MIP‐1β (CCL4) increased significantly 1–3 days after treatment (CCL3, p = 0.0036; CCL4, p = 0.0016, Wilcoxon test). A low pre‐treatment neutrophil‐to‐lymphocyte ratio (NLR) was associated with a better response to therapy and survival.ConclusionsThe release of DAMPs, and cytokine/chemokine production, were detected in the patients' peripheral blood. The baseline NLR may predict patient outcomes in response to NIR‐PIT.
Funder
Japan Society for the Promotion of Science
Subject
Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology