Polyphenol-Rich Fraction fromLarrea divaricataand its Main Flavonoid Quercetin-3-Methyl Ether Induce Apoptosis in Lymphoma Cells Through Nitrosative Stress

Author:

Martino Renzo1,Arcos María Laura Barreiro2,Alonso Rosario1,Sülsen Valeria1,Cremaschi Graciela2,Anesini Claudia1

Affiliation:

1. Instituto de Química y Metabolismo del Fármaco - IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica; Universidad de Buenos Aires; Junín 956 piso 2, 1113, Ciudad Autónoma de Buenos Aires Buenos Aires Argentina

2. Instituto de Investigaciones Biomédicas (BIOMED), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Médicas; Pontificia Universidad Católica Argentina (UCA); Av. A. Moreau de Justo 1600, piso 3, 1107AFF Buenos Aires Argentina

Publisher

Wiley

Subject

Pharmacology

Reference21 articles.

1. Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells;Ash;Am J Cancer Res,2015

2. Organic extracts of Larrea divaricata Cav. induced apoptosis on tumoral MCF7 cells with a higher cytotoxicity than nordihydroguaiaretic acid or paclitaxel;Bongiovanni;J Exp Ther Oncol,2008

3. Antiproliferative activity of Larrea divaricata Cav. on lymphoma cell line: participation of hydrogen peroxide in its action;Davicino;Cancer Invest,2010

4. Larrea divaricata Cav.: scientific evidence showing its beneficial effects and its wide potential application;Davicino;BLACPMA,2011

5. Novel o-naphthoquinones induce apoptosis of EL-4 T lymphoma cells through the increase of reactive oxygen species;Di Rosso;Toxicol In Vitro,2013

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