In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies-Reference-Cited by-同舟云学术

In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies

Published:2018-11-23 Issue:2 Volume:40 Page:230-240
ISSN:1059-7794
Container-title:Human Mutation
language:en
Short-container-title:Human Mutation

Author:

Ismail Hesham M.¹²,Krishnamoorthy Navaneethakrishnan³⁴,Al-Dewik Nader⁵,Zayed Hatem¹,Mohamed Nura A.²,Giacomo Valeria Di⁶,Gupta Sapna⁷,Häberle Johannes⁸^ORCID,Thöny Beat⁸,Blom Henk J.⁹,Kruger Warren D.⁷^ORCID,Ben-Omran Tawfeg⁵,Nasrallah Gheyath K.¹²^ORCID

Affiliation:

1. Department of Biomedical Sciences; College of Health Sciences; Qatar University; Doha Qatar

2. Biomedical Research Center; Qatar University; Doha Qatar

3. Systems Biology Department; Sidra Medical and Research Centre; Doha Qatar

4. Heart Science Centre; National Heart and Lung Institute; Imperial College London; London UK

5. Clinical and Metabolic Genetics; Department of Pediatrics; Hamad Medical Corporation; Doha Qatar

6. ZeClinics SL; PRBB (Barcelona Biomedical Research Park); Barcelona Spain

7. Cancer Biology Program; Fox Chase Cancer Center; Philadelphia Pennsylvania

8. University Children's Hospital and Children's Research Center; Division of Metabolism; Zurich Switzerland

9. Laboratory of Clinical Biochemistry and Metabolism; Department of General Pediatrics; Adolescent Medicine and Neonatology; University Medical Centre Freiburg; Freiburg Germany

Funder

Qatar National Research Fund

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/humu.23682/fullpdf

Reference43 articles.

1. Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma;Amann;Cancer Science,2009

2. Sulfur metabolism actively promotes initiation of cell division in yeast;Blank;Plos One,2009

3. Enzyme replacement with PEGylated cystathionine beta-synthase ameliorates homocystinuria in murine model;Bublil;Journal of Clinical Investigation,2016