BRCA1 and BRCA2 5′ noncoding region variants identified in breast cancer patients alter promoter activity and protein binding-Reference-Cited by-同舟云学术

BRCA1 and BRCA2 5′ noncoding region variants identified in breast cancer patients alter promoter activity and protein binding

Published:2018-09-24 Issue:12 Volume:39 Page:2025-2039
ISSN:1059-7794
Container-title:Human Mutation
language:en
Short-container-title:Human Mutation

Author:

Burke Leslie J.¹^ORCID,Sevcik Jan¹²,Gambino Gaetana¹³,Tudini Emma¹⁴,Mucaki Eliseos J.⁵,Shirley Ben C.⁶,Whiley Phillip¹⁴,Parsons Michael T.⁴,De Leeneer Kim⁷,Gutiérrez-Enríquez Sara⁸,Santamariña Marta⁹,Caputo Sandrine M.¹⁰,Santana dos Santos Elizabeth¹⁰¹¹¹²^ORCID,Soukupova Jana²,Janatova Marketa²,Zemankova Petra²,Lhotova Klara²,Stolarova Lenka²,Borecka Mariana²,Moles-Fernández Alejandro⁸,Manoukian Siranoush¹³,Bonanni Bernardo¹⁴,Edwards Stacey L.⁴,Blok Marinus J.¹⁵,van Overeem Hansen Thomas¹⁶,Rossing Maria¹⁶,Diez Orland⁸¹⁷,Vega Ana⁹,Claes Kathleen B.M.⁷^ORCID,Goldgar David E.¹⁸,Rouleau Etienne¹⁹,Radice Paolo²⁰,Peterlongo Paolo²¹,Rogan Peter K.⁵⁶,Caligo Maria³,Spurdle Amanda B.⁴^ORCID,Brown Melissa A.¹^ORCID,

Affiliation:

1. School of Chemistry and Molecular Biosciences; University of Queensland; Brisbane Australia

2. Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine; Charles University; Prague Czech Republic

3. Section of Molecular Genetics; Department of Laboratory Medicine; University Hospital of Pisa; Pisa Italy

4. Department of Genetics and Computational Biology; QIMR Berghofer Medical Research Institute; Brisbane Australia

5. University of Western Ontario, Department of Biochemistry; Schulich School of Medicine and Dentistry; London Ontario Canada

6. CytoGnomix Inc.; London Ontario Canada

7. Center for Medical Genetics; Ghent University Hospital; and Cancer Research Institute Ghent (CRIG); Ghent University; Ghent Belgium

8. Oncogenetics Group; Vall d'Hebron Institute of Oncology (VHIO); Barcelona Spain

9. Fundación Pública Galega de Medicina Xenómica-SERGAS; Grupo de Medicina Xenómica-USC, CIBERER, IDIS; Santiago de Compostela Spain

10. Service de Génétique; Department de Biologie des Tumeurs; Institut Curie; Paris France

11. Department of oncology; Center for Translational Oncology; Cancer Institute of the State of São Paulo - ICESP; São Paulo Brazil

12. A.C.Camargo Cancer Center; São Paulo Brazil

13. Unit of Medical Genetics; Department of Medical Oncology and Hematology; Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT); Milan Italy

14. Division of Cancer Prevention and Genetics; Istituto Europeo di Oncologia; Milan Italy

15. Department of Clinical Genetics; Maastricht University Medical Centre; Maastricht The Netherlands

16. Center for Genomic Medicine; Copenhagen University Hospital, Rigshospitalet; Copenhagen Denmark

17. Area of Clinical and Molecular Genetics; University Hospital Vall d'Hebron (UHVH); Barcelona Spain

18. Huntsman Cancer Institute; University of Utah; Salt Lake City Utah

19. Gustave Roussy; Villejuif France

20. Unit of Molecular Bases of Genetic Risk and Genetic Testing; Department of Research; Fondazione IRCCS Istituto Nazionale dei Tumori di Milano; Milan Italy

21. IFOM; Fondazione Istituto FIRC di Oncologia Molecolare; Milan Italy

Funder

National Health and Medical Research Council

Cancer Council Queensland

National Cancer Institute

Fondazione Pisa

Miguel Servet Progam

CIBERER

Natural Sciences and Engineering Research Council of Canada

Associazione Italiana per la Ricerca sul Cancro

Canada Research Chairs

Region Hovedstaden