A Systems Pharmacology Model of Erythropoiesis in Mice Induced by Small Molecule Inhibitor of Prolyl Hydroxylase Enzymes-Reference-Cited by-同舟云学术

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A Systems Pharmacology Model of Erythropoiesis in Mice Induced by Small Molecule Inhibitor of Prolyl Hydroxylase Enzymes

Published:2015-02 Issue:2 Volume:4 Page:106-115
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Singh I¹,Nagiec EE²,Thompson JM³,Krzyzanski W¹,Singh P⁴

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical SciencesUniversity at BuffaloBuffalo New York USA

2. Exploratory Drug Safety, Drug Safety Research and Development (DSRD)PfizerCambridge Massachusetts USA

3. Inflammation Biology, Pfizer, Chesterfield, Missouri, USA; Pharmacokinetics‐Dynamics and Metabolism (PDM)PfizerCambridge Massachusetts USA

4. Pharmacokinetics & Drug MetabolismAmgenThousand Oaks California USA

Funder

National Institutes of Health

Pfizer

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12

Reference28 articles.

1. Erythropoiesis-Stimulating Agents — Time for a Reevaluation

2. Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis

3. The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α

4. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

5. A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

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