Loss‐of‐Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia

Author:

Niu Yi1,Lin Ziyou1,Wan Arabella2,Sun Lei1,Yan Shijia1,Liang Heng1,Zhan Siyue1,Chen Dongshi3,Bu Xianzhang1,Liu Peiqing1,Chen Ceshi4,He Weiling25,Lu Xiongbin67,Wan Guohui1ORCID

Affiliation:

1. National‐Local Joint Engineering Laboratory of Druggability and New Drug Evaluation National Engineering Research Center for New Drug and Druggability (cultivation) Guangdong Province Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat‐Sen University Guangzhou China

2. Department of Gastrointestinal Surgery The First Affiliated HospitalSun Yat‐Sen University Guangzhou China

3. Division of Pulmonary, Allergy and Critical Care Medicine Department of Medicine University of Pittsburgh Pittsburgh PA

4. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of Sciences Kunming Yunnan China

5. Center for Precision Medicine Sun Yat‐Sen University Guangzhou China

6. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis IN

7. Indiana University Melvin and Bren Simon Cancer Center Indianapolis IN

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Hepatology

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