The impact of period effects on dose level contrasts in alternating cross-over designs for first-time-in-human studies

Author:

Koehne-Voss Stephan,Schmidli Heinz,Smith David M.,Pigeot Iris

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology,Statistics and Probability

Reference7 articles.

1. Statistical issues in first-in-man studies;Senn;Journal of the Royal Statistical Society, Series A (Statistics in Society),2007

2. How first-time-in-human studies are being performed: a survey of Phase I dose-escalation trials in healthy volunteers published between 1995 and 2004;Buoen;Journal of Clinical Pharmacology,2005

3. Statistical methods for a three-period crossover design in which high dose cannot be used first;Peace;Journal of Biopharmaceutical Statistics,1993

4. Design and analysis issues for crossover designs in Phase I Clinical Studies;Boon;Journal of Biopharmaceutical Statistics,1999

5. The equality of the ordinary least squares estimator and best linear unbiased estimator;Puntanen;The American Statistician,1989

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1. Randomized Controlled Crossover Trial of a New Oscillatory Device as Add-On Therapy for COPD;COPD: Journal of Chronic Obstructive Pulmonary Disease;2012-11-29

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