Direct Toll-Like Receptor 8 signaling increases the functional avidity of human CD8+ T lymphocytes generated for adoptive T cell therapy strategies

Author:

Chatillon Jean-François12,Hamieh Mohamad13,Bayeux Florence2,Abasq Claire124,Fauquembergue Emilie13,Drouet Aurélie3,Guisier Florian124,Latouche Jean-Baptiste134,Musette Philippe124

Affiliation:

1. University of Rouen; Rouen France

2. Institut National de la Santé et de la Recherche Médicale (INSERM) U905; Rouen France

3. INSERM U1079; Rouen France

4. Rouen University Hospital; Rouen France

Funder

Inserm

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference41 articles.

1. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors;Kawai;Nat. Immunol.,2010

2. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines;Zarember;J. Immunol. Baltim. Md 1950,2002

3. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide;Caramalho;J. Exp. Med.,2003

4. Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy;Schreibelt;Cancer Immunol. Immunother.CII,2010

5. Activation of toll-like receptor 2 prevents suppression of T-cell interferon γ production by modulating p38/extracellular signal-regulated kinase pathways following alcohol and burn injury;Li;Mol. Med. Camb. Mass.,2012

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