Degradation of andrographolide in <scp><i>Andrographis paniculata</i></scp> over 1 year storage-Reference-Cited by-同舟云学术

Degradation of andrographolide in Andrographis paniculata over 1 year storage

Published:2024-08-28 Issue: Volume: Page:
ISSN:0958-0344
Container-title:Phytochemical Analysis
language:en
Short-container-title:Phytochemical Analysis

Author:

Ahammed Md. Tanvin¹^ORCID,Sultan Md. Zakir²^ORCID,Hossain Md. Sabbir³^ORCID,Al Mahtab Mamun³^ORCID,Bachar Sitesh Chandra¹^ORCID

Affiliation:

1. Department of Pharmacy University of Dhaka Dhaka Bangladesh

2. Centre for Advanced Research in Sciences (CARS) University of Dhaka Dhaka Bangladesh

3. Department of Hepatology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh

Abstract

AbstractIntroductionAndrographolide is a bioactive component found in the medicinal herb Andrographis paniculata (Burm. f.) Wall. ex Nees (Family—Acanthaceae) is well‐known for its ability to cure liver disorders and as a bitter tonic.ObjectiveIn this study, the rate of degradation of andrographolide was examined over the course of a year of storage.Materials and methodsNew and old (1‐year storage) A. paniculata powder samples were used in the study. High‐performance liquid chromatography (HPLC) was used to assess the concentration of andrographolide after its extraction using ethanol as the solvent.ResultsThe findings demonstrated a 69.26% progressive deterioration of andrographolide over the storage period. Temperature and crystallinity are two factors that affect how quickly andrographolide degrades.ConclusionThe results emphasize how crucial it is to retain the effectiveness of A. paniculata extract by avoiding prolonged storage or by providing ideal storage conditions.

Publisher

Wiley

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