Peptide-MHC class I stability is a better predictor than peptide affinity of CTL immunogenicity

Author:

Harndahl Mikkel1,Rasmussen Michael1,Roder Gustav1,Dalgaard Pedersen Ida1,Sørensen Mikael2,Nielsen Morten2,Buus Søren1

Affiliation:

1. Laboratory of Experimental Immunology; Faculty of Health Sciences; University of Copenhagen; Denmark

2. Center for Biological Sequence Analysis; Department of Systems Biology; Technical University of Denmark; Denmark

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference47 articles.

1. Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability;van der Burg;J. Immunol.,1996

2. The kinetic stability of MHC class II: peptide complexes is a key parameter that dictates immunodominance;Lazarski;Immunity,2005

3. The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II: peptide complexes;Sant;Immunol. Rev.,2005

4. MHC class I/peptide stability: implications for immunodominance, in vitro proliferation, and diversity of responding CTL;Busch;J. Immunol.,1998

5. High peptide affinity for MHC class I does not correlate with immunodominance;Mullbacher;Scand. J. Immunol.,1999

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