Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22-Reference-Cited by-同舟云学术

Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22

Published:2021-06-05 Issue:5 Volume:5 Page:
ISSN:2475-0379
Container-title:Research and Practice in Thrombosis and Haemostasis
language:en
Short-container-title:Res Pract Thromb Haemost

Author:

Yoshitomi Toru¹²,Wakui Koji¹,Miyakawa Masato¹,Yoshimoto Keitaro¹³

Affiliation:

1. Department of Life Sciences Graduate School of Arts and Sciences The University of Tokyo Tokyo Japan

2. Research Center for Functional Materials National Institute for Materials Science Ibaraki Japan

3. JSTPRESTO Tokyo Japan

Publisher

Wiley

Subject

Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/rth2.12503

Reference19 articles.

1. Selection Technologies and Applications of Nucleic Acid Aptamers

2. Screening of DNA Signaling Aptamer from Multiple Candidates Obtained from SELEX with Next-generation Sequencing

3. Binding and Structural Properties of DNA Aptamers with VEGF-A-Mimic Activity

4. Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX

5. Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant

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1. A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice;Molecular Therapy - Nucleic Acids;2023-09

2. Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands;International Journal of Molecular Sciences;2021-10-06