Utility of a next‐generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide-Reference-Cited by-同舟云学术

Utility of a next‐generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide

Published:2021-11 Issue:9 Volume:62 Page:512-525
ISSN:0893-6692
Container-title:Environmental and Molecular Mutagenesis
language:en
Short-container-title:Environ Mol Mutagen

Author:

Nicolette John¹,Luijten Mirjam²,Sasaki Jennifer C.³,Custer Laura⁴,Embry Michelle⁵,Froetschl Roland⁶^ORCID,Johnson George⁷^ORCID,Ouedraogo Gladys⁸,Settivari Raja⁹,Thybaud Veronique¹⁰,Dearfield Kerry L.¹¹

Affiliation:

1. AbbVie, Inc. North Chicago Illinois USA

2. Centre for Health Protection National Institute for Public Health and the Environment (RIVM) Bilthoven The Netherlands

3. Seagen Inc. Bothell Washington USA

4. Bristol‐Myers Squibb Company, Drug Safety Evaluation New Brunswick New Jersey USA

5. Health and Environmental Sciences Institute Washington District of Columbia USA

6. Federal Institute for Drugs and Medical Devices Bonn Germany

7. Swansea University Medical School Swansea University Swansea UK

8. L'Oréal Recherche & Innovation Aulnay‐Sous‐Bois France

9. Corteva Agriscience Newark Delaware USA

10. Sanofi, Research & Development Chilly‐Mazarin France

11. Retired Burke Virginia USA

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics(clinical),Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/em.22467

Reference78 articles.

1. Etoposide (VP-16): Cytogenetic studies in mice

2. potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: Comparison to salmonella responses

3. Etoposide and merbarone are clastogenic and aneugenic in the mouse bone marrow micronucleus test complemented by fluorescence in situ hybridization with the mouseminor satellite DNA probe

4. Potential impurities in drug substances: Compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides

5. Endocrinological late effects after chemotherapy for testicular cancer

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