Affiliation:
1. Institute for Materials Discovery University College London WC1H 0AJ London UK
2. Department of Chemistry University College London WC1H 0AJ London UK
3. School of Electrical Engineering and Computer Science Gwangju Institute of Science and Technology Cheomdangwagi‐ro 123 61005 Gwangju Republic of Korea
Abstract
AbstractHybrid plasmonic nanojunctions with optimal surface‐enhanced Raman scattering (SERS) activity are designed via a computer‐aided approach, and fabricated via time‐controlled aqueous self‐assembly of core@shell gold@silver nanoparticles (Au@Ag NPs) with cucurbit[7]uril (CB7) upon simple mixing. The authors showed that SERS signals can be significantly boosted by the incorporation of a strong plasmonic metal and the spectral alignment between the maximal localized surface plasmon resonance (LSPR) and a laser wavelength used for SERS excitation. In a proof‐of‐concept application, SERS detection of nucleobases with a 633‐nm laser has been demonstrated by positioning them within the nanojunctions via formation of host–guest complexes with CB7, achieving rapid response with a detection limit down to sub‐nanomolar concentration and an enhancement factor (EF) up to ≈109–1010, i.e., the minimum required EF for single‐molecule detection. Furthermore, machine‐learning‐driven multiplexing of nucleobases is demonstrated, which shows promise in point‐of‐care diagnosis of diseases related to oxidative damage of DNA and wastewater‐based epidemiology.
Funder
Leverhulme Trust
National Research Foundation of Korea
Subject
Industrial and Manufacturing Engineering,Mechanics of Materials,General Materials Science
Cited by
6 articles.
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