Affiliation:
1. Division of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China
2. University of Chinese Academy of Sciences Beijing 100049 China
3. Beijing Institute for Stem Cell and Regenerative Medicine Chinese Academy of Sciences Beijing 100049 China
4. University of Science and Technology of China Hefei 230026 China
5. Suzhou Institute for Advanced Research University of Science and Technology of China Suzhou 215123 China
Abstract
AbstractSkeletal muscle contributes significantly to human health, which is closely relevant to human locomotion, energy metabolism, immune regulation, and aging. Skeletal muscle holds the potential to recover its healthy condition via self‐repairing after minor damage. However, the capacity of sarcous self‐repair becomes incompetent following massive trauma or some myopathy, which raises a huge demand for skeletal muscle regeneration. Skeletal muscle engineering aims to rebuild muscle tissues in vitro to repair muscle injuries, develop pathological models, advance myopathy‐related research, and explore myopathy‐related medications. This review summarizes the advances in skeletal muscle engineering, including the cell resources that can be used in muscle regeneration, the recent progress of rebuilding methods for skeletal muscle engineering, as well as the biomedical applications of engineered skeletal muscle for tissue repair, drug testing, disease modeling, and soft robots. Finally, the challenges and future perspectives are discussed on improving skeletal muscle engineering by integrating multidisciplinary approaches, thus accelerating the technological innovation and translational application of this area.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Yunnan Key Research and Development Program
Subject
Industrial and Manufacturing Engineering,Mechanics of Materials,General Materials Science