Programmable Delivery of Fluoxetine via Wearable Bioelectronics for Wound Healing In Vivo

Author:

Li Houpu1,Yang Hsin‐ya2,Asefifeyzabadi Narges1,Baniya Prabhat1,Lopez Andrea Medina2,Gallegos Anthony2,Zhu Kan3,Nguyen Tiffany1,Hernandez Cristian1,Zlobina Ksenia4,Recendez Cynthia3,Hsieh Hao‐Chieh15,Tebyani Maryam1,Carrión Héctor6,Selberg John1,Luo Le1,Alhamo Moyasar A.2,Barbee Alexie1,Orozco Jonathan1,Hsieh Cathleen5,Soulika Athena M.27,Levin Michael8,Norouzi Narges6,Gomez Marcella4,Zhao Min3,Teodorescu Mircea1,Isseroff Roslyn Rivkah29,Rolandi Marco1ORCID

Affiliation:

1. Department of Electrical and Computer Engineering University of California Santa Cruz Santa Cruz CA 95064 USA

2. Department of Dermatology School of Medicine University of California Davis Davis CA 95616 USA

3. Department of Ophthalmology School of Medicine University of California Davis Davis CA 95616 USA

4. Department of Applied Mathematics University of California Santa Cruz Santa Cruz CA 95064 USA

5. Department of Chemistry and Biochemistry University of California Santa Cruz Santa Cruz CA 95064 USA

6. Department of Computer Science and Engineering University of California Santa Cruz Santa Cruz CA 95064 USA

7. Pediatric Regenerative Medicine Shriners Hospitals for Children Sacramento CA 95817 USA

8. Department of Biology Tufts University Medford MA 02155 USA

9. Dermatology Section VA Northern California Health Care System Mather CA 95655 USA

Abstract

AbstractThe ability to deliver drugs with precise dosages at specific time points can significantly improve disease treatment while reducing side effects. Drug encapsulation for gradual delivery has opened the doors for a superior treatment regimen. To expand on this ability, programming bioelectronic devices to deliver small molecules enables ad‐hoc personalized therapeutic profiles that are more complex than gradual release. Here, a wearable bioelectronic device with an integrated electrophoretic ion pump that affords on‐demand drug delivery with precise dose control is introduced. Delivery of fluoxetine to wounds in mice result in a 27.2% decrease in the macrophage ratio (M1/M2) and a 39.9% increase in re‐epithelialization, indicating a shorter inflammatory phase and faster overall healing. Programmable drug delivery using wearable bioelectronics in wounds introduces a broadly applicable strategy for the long‐term delivery of a prescribed treatment regimen with minimal external intervention.

Funder

Defense Sciences Office, DARPA

Publisher

Wiley

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