Polyethylene Glycol‐Stabilized Gold Nanostars‐Loaded Microneedles for Photothermal Therapy of Melanoma

Author:

El‐Sayed Nesma12,Elbadri Khalil1,Correia Alexandra1,Santos Hélder A.134ORCID

Affiliation:

1. Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki 00014 Finland

2. Department of Pharmaceutics Faculty of Pharmacy Alexandria University Alexandria 21521 Egypt

3. Department of Biomedical Engineering University Medical Center Groningen University of Groningen Ant. Deusinglaan 1 Groningen 9713 AV The Netherlands

4. W.J. Kolff Institute for Biomedical Engineering and Materials Science University Medical Center Groningen University of Groningen Ant. Deusinglaan 1 Groningen 9713 AV The Netherlands

Abstract

AbstractGold nanostars (GNSs) as a photothermal agent have shown great potential for the treatment of cancers like melanoma. Irradiation of the photothermal agents with light of a suitable wavelength generates heat that induces cellular stress and protein denaturation in cancer cells. The delivery of GNSs to skin using fast dissolving microneedles (MNs) presents a promising approach for painless and convenient administration of the therapy. In this study, polyethylene glycol (PEG) stabilized GNSs able to absorb light in the near‐infra red region and release heat (up to 65 °C, room temperature) are developed. The cytotoxicity of these nanoparticles is assessed before and after exposure to laser irradiation. GNSs show an instant lethal photothermal effect when tested on B16F10 melanoma cells upon irradiation with 808 nm at a power of 800 mW for 10 min. Loading the GNSs in polyvinylpyrrolidone (PVP) MNs preserves the photothermal effect of GNS and the mechanical properties of MNs. GNS‐loaded PVP MNs show efficient piercing in excised porcine skin, fast dissolution in 3 min after insertion and elevation of the skin temperature after laser irradiation (808 nm, 800 mW, 10 min) to 63 °C. Consequently, PEG‐stabilized GNSs and PVP MNs are a promising platform for photothermal therapy in melanoma treatment.

Funder

Business Finland

Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta

Publisher

Wiley

Subject

Industrial and Manufacturing Engineering,Mechanics of Materials,General Materials Science

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