Safety and pharmacokinetics of the oral iron chelator SP-420 in β-thalassemia

Author:

Taher Ali T.1ORCID,Saliba Antoine N.2,Kuo Kevin H.3ORCID,Giardina Patricia J.4,Cohen Alan R.5,Neufeld Ellis J.6,Aydinok Yesim7,Kwiatkowski Janet L.5,Jeglinski Brenda I.8,Pietropaolo Keith8,Berk Gregory8,Viprakasit Vip9ORCID

Affiliation:

1. Department of Internal Medicine; American University of Beirut Medical Center; Beirut Lebanon

2. Department of Medicine; Indiana University School of Medicine; Indianapolis Indiana

3. Division of Medical Oncology and Hematology; University Health Network; Toronto Ontario Canada

4. Weill Medical College of Cornell University; New York New York

5. Division of Hematology, The Children's Hospital of Philadelphia and Perelman School of Medicine of the University of Pennsylvania; Philadelphia Pennsylvania

6. St. Jude Children's Research Hospital; Memphis Tennessee

7. Department of Pediatric Hematology; Ege University Hospital; Izmir Turkey

8. Sideris Pharmaceuticals, Inc.; Lexington Massachusetts

9. Department of Pediatrics & Thalassemia Center; Faculty of Medicine Siriraj Hospital, Mahidol University; Bangkok Thailand

Funder

Sideris Pharmaceuticals, Inc

Publisher

Wiley

Subject

Hematology

Reference16 articles.

1. Iron-chelating therapy for transfusional iron overload;Brittenham;N Engl J Med.,2011

2. How I treat transfusional iron overload;Hoffbrand;Blood.,2012

3. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload;Piga;Haematologica.,2006

4. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine;Borgna-Pignatti;Haematologica.,2004

5. Deferiprone versus deferoxamine in patients with thalassemia major: a randomized clinical trial;Maggio;Blood Cells Mol Dis.,2002

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