A new paradigm for classifying and treating HER2‐positive breast cancer

Author:

He Xuexin1ORCID,Yeung Sai‐Ching J.2ORCID,Esteva Francisco J.3

Affiliation:

1. Department of Medical Oncology Huashan Hospital of Fudan University Shanghai China

2. Division of Internal Medicine MD Anderson Cancer Center Houston Texas USA

3. Division of Hematology/Oncology Northwell Health Cancer Institute at Lenox Hill Hospital New York New York USA

Abstract

AbstractBackgroundBecause of the phenomenal success of treatment with monoclonal antibodies and antibody‐drug conjugates targeting human epidermal growth factor receptor 2 (HER2), most patients with early‐stage HER2‐positive breast cancer (HER2+ BC) and some with limited metastatic diseases have been cured, and those who have not been cured have achieved significant improvements in overall survival, which has weakened the role of the TNM staging system in the prognosis of HER2+ BC today. Given that the disease is now highly curable, treatment conception, classification, and modalities should differ from those of cancer types with a poor prognosis. It is warranted to build a new paradigm for classifying and treating HER2+ BC.Recent findingsIn our personal view, we suggest that the classification system should be based not only on traditional anatomy and cancer biology but also on available treatment regimens, their exceptional outcomes, and their toxicities. In this regard, we developed a new concise classification of HER2+ BC based on the TNM staging system, a review of the literature, research results, and our clinical experience, dividing the patients into four distinct groups: curable (lymph‐node negative and small (≤3 cm) early breast cancer), do our best to cure (locally advanced or tumors >3 cm early breast cancer), hope for cure (local‐regional recurrent, limited metastases, and exceptional responders), and incurable (metastatic breast cancer with poor performance status or non‐exceptional responders).ConclusionIt will assist clinicians in developing an optimal treatment regimen at the outset, curing more HER2+ BC patients and improving their quality of life.

Publisher

Wiley

Subject

Cancer Research,Oncology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. HER2-low metastatic breast cancer: molecular insights and therapeutic strategies;Journal of Cancer Metastasis and Treatment;2023-11-30

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