Affiliation:
1. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China
2. State Key Laboratory of Modern Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education Tianjin University of Traditional Chinese Medicine Tianjin China
3. Department of Cardiac Surgery, Frankel Cardiovascular Center University of Michigan Ann Arbor Michigan USA
Abstract
AbstractCardiovascular disease (CVD) has become a severe threat to human health, with morbidity and mortality increasing yearly and gradually becoming younger. When the disease progresses to the middle and late stages, the loss of a large number of cardiomyocytes is irreparable to the body itself, and clinical drug therapy and mechanical support therapy cannot reverse the development of the disease. To explore the source of regenerated myocardium in model animals with the ability of heart regeneration through lineage tracing and other methods, and develop a new alternative therapy for CVDs, namely cell therapy. It directly compensates for cardiomyocyte proliferation through adult stem cell differentiation or cell reprogramming, which indirectly promotes cardiomyocyte proliferation through non‐cardiomyocyte paracrine, to play a role in heart repair and regeneration. This review comprehensively summarizes the origin of newly generated cardiomyocytes, the research progress of cardiac regeneration based on cell therapy, the opportunity and development of cardiac regeneration in the context of bioengineering, and the clinical application of cell therapy in ischemic diseases.
Funder
National Natural Science Foundation of China
Subject
Cell Biology,Clinical Biochemistry,Physiology