Protein turnover: Measurement of proteome dynamics by whole animal metabolic labelling with stable isotope labelled amino acids

Author:

Claydon Amy J.1,Thom Michael D.2,Hurst Jane L.2,Beynon Robert J.1

Affiliation:

1. Protein Function Group, Institute of Integrative Biology; University of Liverpool; Liverpool UK

2. Mammalian Behaviour and Evolution Group; Institute of Integrative Biology; University of Liverpool; Leahurst Campus; Neston UK

Funder

EPSRC

NERC

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Reference38 articles.

1. The application of the nitrogen isotope N15 for the study of protein metabolism;Schoenheimer;Science,1938

2. Synthesis/degradation ratio mass spectrometry for measuring relative dynamic protein turnover;Cargile;Anal. Chem,2004

3. Measurement of human plasma proteome dynamics with (2)H(2)O and liquid chromatography tandem mass spectrometry;Price;Anal. Biochem,2011

4. Measuring proteome dynamics in vivo: as easy as adding water?;Rachdaoui;Mol. Cell Proteomics,2009

5. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations;Hellerstein;Am. J. Physiol,1999

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