Effect of genetic polymorphisms of interleukin‐1 beta on the microscopic portal vein invasion and prognosis of hepatocellular carcinoma

Abstract

AbstractBackgroundSeveral studies have demonstrated a relationship between genetic polymorphisms of interleukin‐1 beta (IL‐1β) and cancer development; however, their influence on cancer prognosis is unknown. In the present study, we aimed to evaluate the impact of IL‐1β single nucleotide polymorphisms on the hematogenous dissemination and prognosis of hepatocellular carcinoma.MethodsWe conducted a retrospective cohort study including patients with hepatocellular carcinoma who underwent primary liver resection at our hospital between April 2015 and December 2018. The primary endpoints were overall and recurrence‐free survival. Secondary endpoints were microscopic portal vein invasion and number of circulating tumor cells.ResultsA total of 148 patients were included, 32 with rs16944 A/A genotype. A/A genotype was associated with microscopic portal vein invasion and number of circulating tumor cells (p = .03 and .04). In multivariate analysis, A/A genotype, alpha‐fetoprotein level, and number of circulating tumor cells were associated with microscopic portal vein invasion (p = .01, .01, and <.01). A/A genotype, Child‐Pugh B, and intraoperative blood loss were independent predictive factors for overall survival (p = .02, <.01, and <.01).ConclusionsOur results indicate that the IL‐1β rs16944 A/A genotype is involved in number of circulating tumor cells, microscopic portal vein invasion, and prognosis in HCC.