Epidemiologic, clinical and therapeutic features of primary cutaneous lymphomas in Morocco

Author:

Hali Fouzia1,Zakaryaa Salma1ORCID,Senouci Karima2,Zeggwagh Zineb2,Mernissi Fatima Zahra3,Elloudi Sara3,Hashas Fatima Zahra3,Amal Said4,Hocar Ouafa4,Aboudourib Maryem4,Kelati Awatef5ORCID,Chikhaoui Inas5,Quessar Asmaa6,Chiheb Soumiya1

Affiliation:

1. Department of Dermatology and Venereology Ibn Rochd University Hospital Casablanca Morocco

2. Department of Dermatology and Venereology Ibn Sina University Hospital Rabat Morocco

3. Dermatology and Venereology Department Hassan II University Hospital Fez Morocco

4. Department of Dermatology and Venereology Mohamed VI University Hospital Marrakech Morocco

5. Department of Dermatology and Venereology Cheikh Khalifa University Hospital Casablanca Morocco

6. Department of Haematology and Paediatric Oncology 20 Aout Hospital Casablanca Morocco

Abstract

AbstractBackgroundFew epidemiological studies on primary cutaneous lymphomas are available and related to limited populations.ObjectivesTo characterize the epidemiologic, clinical and therapeutic features of primary cutaneous lymphomas from a global perspective at the national level.MethodsA cross‐sectional descriptive multicenter study including patients treated for cutaneous lymphomas at dermatology and venereology departments of different university hospitals in the kingdom of Morocco from January 2012 to December 2021.ResultsOur multicenter cohort consisted of 402 patients. The median age was 56 years (15–114) with a male predominance (61%, 245 cases). Based on the WHO‐EORTC classification, the most frequent histological type was cutaneous T‐cell lymphoma (CTCL) (88% of cases). Of these, mycosis fungoides (MF) was the most common (78%). B‐cell lymphomas represented 12% of cases, mainly centro‐follicular B‐cell lymphoma (40%). The clinical presentation was most frequently erythematous and scaly infiltrated lesions in 187 CTCL patients (52.6%), and nodular lesions in 37 patients (78%) with B‐cell lymphomas. Treatment modalities depended on the tumour's histological type and stage and included: topical corticosteroids and phototherapy in 52% of cases, monochemotherapy, radiotherapy, photopheresis and polychemotherapy. The evolution was marked by remission in 41% of patients, relapse in 17% and death in 12%.ConclusionsOur national study provides data on primary cutaneous lymphomas in Morocco, never before mentioned in indexed literature. We identified 402 cases over a 10‐year period. A better knowledge of these entities is key to optimize diagnosis and therapy.

Publisher

Wiley

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