Positron Emission Tomography Imaging of [ 11 C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of Cyclosporin A

Author:

Billington Sarah12,Shoner Steven3,Lee Scott4,Clark‐Snustad Kindra4ORCID,Pennington Matthew5,Lewis David3,Muzi Mark3,Rene Shirley3,Lee Jean3,Nguyen Tot Bui1,Kumar Vineet1,Ishida Kazuya16,Chen Laigao7,Chu Xiaoyan8,Lai Yurong9ORCID,Salphati Laurent10,Hop Cornelis E.C.A.10,Xiao Guangqing1112,Liao Mingxiang12,Unadkat Jashvant D.1

Affiliation:

1. Department of PharmaceuticsUniversity of Washington Seattle Washington USA

2. Drug Metabolism and PharmacokineticsVertex Pharmaceuticals (Europe) Ltd. Abingdon‐on‐Thames UK

3. Department of RadiologyUniversity of Washington Seattle Washington USA

4. Inflammatory Bowel Disease ProgramUniversity of Washington Seattle Washington USA

5. Department of Anesthesiology & Pain MedicineUniversity of Washington Seattle Washington USA

6. Pharmacokinetics and Drug MetabolismAmgen Cambridge Massachusetts USA

7. Early Clinical DevelopmentWorldwide Research and DevelopmentPfizer Inc. Cambridge Massachusetts USA

8. Pharmacokinetics, Pharmacodynamics, and Drug MetabolismMerck & Co. Kenilworth New Jersey USA

9. Department of Drug MetabolismGilead Sciences, Inc. Foster City California USA

10. Drug Metabolism and PharmacokineticsGenentech, Inc. South San Francisco California USA

11. Drug Metabolism and PharmacokineticsBiogen Cambridge Massachusetts USA

12. Department of Drug Metabolism and PharmacokineticsTakeda Pharmaceuticals International Co. Cambridge Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

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