Rational Design of Orally Administered Cascade Nanozyme for Inflammatory Bowel Disease Therapy

Author:

Yu Yixin1,Zhao Xianguang2,Xu Xudong2,Cai Chenwen2,Tang Xuemei3,Zhang Qingyun3,Zhong Liang2,Zhou Fusheng2,Yang Dongqin3,Zhu Zhiling1ORCID

Affiliation:

1. College of Materials Science and Engineering Qingdao University of Science and Technology 53 Zhengzhou Road Qingdao Shandong 266042 China

2. Department of Digestive Diseases Huashan Hospital Fudan University 12 Middle Urumqi Road Shanghai 200040 China

3. Central Laboratory Huashan Hospital Fudan University 12 Middle Urumqi Road Shanghai 200040 China

Abstract

AbstractInflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric reactive oxygen species (ROS) play critical roles in the physiology and pathology of IBD. Nanozymes hold great promise for the treatment of IBD because of their exceptional ability to regulate redox homeostasis during ROS‐related inflammation. However, the rapid development of orally administered, acid‐tolerant, antioxidant nanozymes for IBD therapy is challenging. Here, a nine‐tier high‐throughput screening strategy is established to address the multifaceted IBD treatment demands, including intrinsic stability, radioactivity, solubility, gut microbiome toxicity, biomimetic elements, intermediate frontier molecular orbitals, reaction energy barriers, negative charges, and acid tolerance. Ni3S4 is selected as the best matching material from 146 323 candidates, which exhibits superoxide dismutase‐catalase bienzyme‐like activity and is 3.13‐ and 1.80‐fold more active than natural enzymes. As demonstrated in a mouse model, Ni3S4 is stable in the gastrointestinal tract without toxicity and specifically targets the diseased colon to alleviate oxidative stress. RNA and 16S rRNA sequencing analyses show that Ni3S4 effectively inhibits the cellular pathways of pro‐inflammatory factors and restores the gut microbiota. This study not develops a highly efficient orally administered cascade nanozyme for IBD therapy and offers a next‐generation paradigm for the rational design of nanomedicine through data‐driven approaches.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3