Affiliation:
1. Department of Orthopedics and Trauma Peking University People's Hospital Key Laboratory of Trauma and Neural Regeneration (Peking University) Ministry of Education National Center for Trauma Medicine Beijing 100044 China
2. Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research Institute School of Chemistry & Biological Engineering University of Science and Technology Beijing Beijing 100083 China
Abstract
AbstractTrauma often results in peripheral nerve injuries (PNIs). These injuries are particularly challenging therapeutically because of variable nerve diameters, slow axonal regeneration, infection of severed ends, fragility of the nerve tissue, and the intricacy of surgical intervention. Surgical suturing is likely to cause additional damage to peripheral nerves. Therefore, an ideal nerve scaffold should possess good biocompatibility, diameter adaptability, and a stable biological interface for seamless biointegration with tissues. Inspired by the curl of Mimosa pudica, this study aimed to design and develop a diameter‐adaptable, suture‐free, stimulated curling bioadhesive tape (SCT) hydrogel for repairing PNI. The hydrogel is fabricated from chitosan and acrylic acid‐N‐hydroxysuccinimide lipid via gradient crosslinking using glutaraldehyde. It closely matches the nerves of different individuals and regions, thereby providing a bionic scaffold for axonal regeneration. In addition, this hydrogel rapidly absorbs tissue fluid from the nerve surface achieving durable wet‐interface adhesion. Furthermore, the chitosan‐based SCT hydrogel loaded with insulin‐like growth factor‐I effectively promotes peripheral nerve regeneration with excellent bioactivity. This procedure for peripheral nerve injury repair using the SCT hydrogel is simple and reduces the difficulty and duration of surgery, thereby advancing adaptive biointerfaces and reliable materials for nerve repair.
Funder
National Natural Science Foundation of China
Ministry of Education of the People's Republic of China
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献