Affiliation:
1. State Key Laboratory of Fine Chemicals College of Materials Science and Engineering Shenzhen University Shenzhen 518071 China
2. Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 China
3. State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Dalian University of Technology Dalian 116024 China
4. College of Chemistry and Environmental Engineering Shenzhen University Shenzhen Guangdong 518060 China
5. State Key Laboratory of Materials‐Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Nanjing 211816 China
Abstract
AbstractAs an iron‐dependent lipid peroxidation (LPO) mediated cell death pathway, ferroptosis offers promises for anti‐tumor treatment. Photodynamic therapy (PDT) is an ideal way to generate reactive oxygen species (ROS) for LPO. However, the conventional PDT normally functions on subcellular organelles, such as endoplasmic reticulum, mitochondria, and lysosome, causing rapid cell death before triggering ferroptosis. Herein, the first lipid droplet (Ld)‐targeting type I photosensitizer (PS) with enhanced superoxide anion (O2−·) production, termed MNBS, is reported. The newly designed PS selectively localizes at Ld in cells, and causes cellular LPO accumulation by generating sufficient O2−· upon irradiation, and subsequently induces ferroptosis mediated chronical PDT, achieving high‐efficient anti‐tumor PDT in hypoxia and normoxia. Theoretical calculations and comprehensive characterizations indicate that the Ld targeting property and enhanced O2−· generation of MNBS originate from the elevated H‐aggregation tendency owing to dispersed molecular electrostatic distribution. Further in vivo studies using MNBS‐encapsulated liposomes demonstrate the excellent anti‐cancer efficacy as well as anti‐metastatic activity. This study offers a paradigm of H‐aggregation reinforced type I PS to achieve ferroptosis‐mediated PDT.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
1 articles.
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