Bioadhesives with Antimicrobial Properties

Author:

Nakipoglu Mustafa123ORCID,Tezcaner Ayşen24ORCID,Contag Christopher H.56ORCID,Annabi Nasim17ORCID,Ashammakhi Nureddin567ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering University of California, Los Angeles Los Angeles CA 90095 USA

2. Department of Engineering Sciences School of Natural and Applied Sciences Middle East Technical University Ankara 06800 Turkey

3. Department of Molecular Biology and Genetics Faculty of Sciences Bartin University Bartin 74000 Turkey

4. BIOMATEN, CoE in Biomaterials & Tissue Engineering Middle East Technical University Ankara 06800 Turkey

5. Institute for Quantitative Health Science and Engineering Michigan State University East Lansing MI 48824 USA

6. Department of Biomedical Engineering College of Engineering Michigan State University East Lansing MI 48824 USA

7. Department of Bioengineering University of California, Los Angeles Los Angeles CA 90095 USA

Abstract

AbstractBioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such as suturing and stapling. Composed of natural or synthetic polymers, these bioadhesives seal wounds and facilitate healing while preventing infections through the activity of locally released antimicrobial drugs, nanocomponents, or inherently antimicrobial polers. Although many different materials and strategies are employed to develop antimicrobial bioadhesives, the design of these biomaterials necessitates a prudent approach as achieving all the required properties including optimal adhesive and cohesive properties, biocompatibility, and antimicrobial activity can be challenging. Designing antimicrobial bioadhesives with tunable physical, chemical, and biological properties will shed light on the path for future advancement of bioadhesives with antimicrobial properties. In this review, the requirements and commonly used strategies for developing bioadhesives with antimicrobial properties are discussed. In particular, different methods for their synthesis and their experimental and clinical applications on a variety of organs are reviewed. Advances in the design of bioadhesives with antimicrobial properties will pave the way for a better management of wounds to increase positive clinical outcomes.

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

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