Affiliation:
1. Department of Chemical Engineering Pohang University of Science and Technology 77 Cheongam‐ro Pohang 37673 Republic of Korea
2. Division of Smart Healthcare Pukyong National University 45 Yongso‐ro Busan 48513 Republic of Korea
3. Institute of Medical Devices Kangwon National University 1 Gangwondaehak‐gil Chuncheon 24341 Republic of Korea
4. Medical Device Development Center Daegu‐Gyeongbuk Medical Innovation Foundation 80 Cheombok‐ro Daegu 41061 Republic of Korea
5. Medical Science and Engineering School of Convergence Science and Technology Pohang University of Science and Technology 77 Cheongam‐ro Pohang 37673 Republic of Korea
Abstract
AbstractCustomizable bioadhesives for individual organ requirements, including tissue type and motion, are essential, especially given the rise in implantable medical device applications demanding adequate underwater adhesion. While synthetic bioadhesives are widely used, their toxicity upon degradation shifts focus to biocompatible natural biomaterials. However, enhancing the adhesive strengths of these biomaterials presents ongoing challenges while accommodating the unique properties of specific organs. To address these issues, three types of customized underwater bioadhesive patches (CUBAPs) with strong, water‐responsive adhesion and controllable biodegradability and stretchability based on bioengineered mussel adhesive proteins conjugated with acrylic acid and/or methacrylic acid are proposed. The CUBAP system, although initially nonadhesive, shows strong underwater adhesion upon hydration, adjustable biodegradation, and adequate physical properties by adjusting the ratio of poly(acrylic acid) and poly(methacrylic acid). Through ex vivo and in vivo evaluations using defective organs and the implantation of electronic devices, the suitability of using CUBAPs for effective wound healing in diverse internal organs is demonstrated. Thus, this innovative CUBAP system offers strong underwater adhesiveness with tailored biodegradation timing and physical properties, giving it great potential in various biomedical applications.
Funder
National Research Foundation of Korea
Ministry of Science and ICT, South Korea
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献