A Totipotent “All‐In‐One” Peptide Sequentially Blocks Immune Checkpoint and Reverses the Immunosuppressive Tumor Microenvironment

Author:

Zhang Limin1,Jiang Zhenqi12ORCID,Yang Xi13,Qian Yixia4,Wang Minxuan1,Wu Shang1,Li Lingyun1,Jia Fei4,Wang Zihua5,Hu Zhiyuan4,Zhao Minzhi4,Tang Xiaoying1,Li Gang6,Shang Hanbing7,Chen Xiaoyuan8910,Wang Weizhi1ORCID

Affiliation:

1. Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information Technology Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electro‐photonic Conversion Materials School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China

2. School of Medical Technology Beijing Institute of Technology Beijing 100081 P.R. China

3. Cancer Institute Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 201203 P. R. China

4. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 P. R. China

5. Centre for Neuroscience Research School of Basic Medical Sciences Fujian Medical University Fuzhou Fujian 350108 P. R. China

6. Gastrointestinal Surgery Shanxi Hospital of Traditional Chinese Medicine Taiyuan 030012 P. R. China

7. Department of Surgery Ruijin Hospital Shanghai Jiaotong University Shanghai 200025 P. R. China

8. Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore

9. Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

10. Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

National University of Singapore

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials,General Materials Science

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