Affiliation:
1. International Joint Research Laboratory for Biointerface and Biodetection State Key Lab of Food Science and Resources School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 P. R. China
2. Wenzhou Institute University of Chinese Academy of Sciences, and Oujiang Laboratory Wenzhou Zhejiang 325001 P. R. China
Abstract
AbstractThe chemical, physical and biological effects of chiral nanomaterials have inspired general interest and demonstrated important advantages in fundamental science. Here, chiral iron oxide supraparticles (Fe3O4 SPs) modified by chiral penicillamine (Pen) molecules with g‐factor of ≈2 × 10−3 at 415 nm are fabricated, and these SPs act as high‐quality magnetic resonance imaging (MRI) contrast agents. Therein, the transverse relaxation efficiency and T2‐MRI results demonstrated chiral Fe3O4 SPs have a r2 relaxivity of 157.39 ± 2.34 mM−1·S−1 for D‐Fe3O4 SPs and 136.21 ± 1.26 mM−1·S−1 for L‐Fe3O4 SPs due to enhanced electronic transition dipole moment for D‐Fe3O4 SPs compared with L‐Fe3O4 SPs. The in vivo MRI results show that D‐Fe3O4 SPs exhibit two‐fold lower contrast ratio than L‐Fe3O4 SPs, which enhances targeted enrichment in tumor tissue, such as prostate cancer, melanoma and brain glioma tumors. Notably, it is found that D‐Fe3O4 SPs have 7.7‐fold higher affinity for the tumor cell surface receptor cluster‐of‐differentiation 47 (CD47) than L‐Fe3O4 SPs. These findings uncover that chiral Fe3O4 SPs act as a highly effective MRI contrast agent for targeting and imaging broad tumors, thus accelerating the practical application of chiral nanomaterials and deepening the understanding of chirality in biological and non‐biological environments.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
1 articles.
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