Bias‐Free Cardiac Monitoring Capsule

Author:

Qu Xuecheng12,Cheng Sijing3,Liu Ying1,Hu Yiran34,Shan Yizhu15,Luo Ruizeng15,Weng Sixian3,Li Hui6,Niu Hongxia3,Gu Min3,Fan Yubo7,Shi Bojing7,Liu Zhuo17,Hua Wei3,Li Zhou15ORCID,Wang Zhong Lin18

Affiliation:

1. Beijing Key Laboratory of Micro‐Nano Energy and Sensor Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 China

2. State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical Engineering Tsinghua University Beijing 100084 China

3. The Cardiac Arrhythmia Center State Key Laboratory of Cardiovascular Disease National Clinical Research Center of Cardiovascular Diseases Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

4. Department of Cardiology and Macrovascular Disease Beijing Tiantan Hospital Capital Medical University Beijing 100070 China

5. School of Nanoscience and Technology University of Chinese Academy of Sciences Beijing 100049 China

6. Department of Ultrasound State Key Laboratory of Cardiovascular Disease National Clinical Research Center of Cardiovascular Diseases Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

7. Key Laboratory of Biomechanics and Mechanobiology Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering Medicine Beihang University Beijing 100191 China

8. Georgia Institute of Technology Atlanta GA 30332‐0245 USA

Abstract

AbstractCardiovascular disease (CVD) remains the leading cause of death worldwide. Patients often fail to recognize the early signs of CVDs, which display irregularities in cardiac contractility and may ultimately lead to heart failure. Therefore, continuously monitoring the abnormal changes in cardiac contractility may represent a novel approach to long‐term CVD surveillance. Here, a zero‐power consumption and implantable bias‐free cardiac monitoring capsule (BCMC) is introduced based on the triboelectric effect for cardiac contractility monitoring in situ. The output performance of BCMC is improved over 10 times with nanoparticle self‐adsorption method. This device can be implanted into the right ventricle of swine using catheter intervention to detect the change of cardiac contractility and the corresponding CVDs. The physiological signals can be wirelessly transmitted to a mobile terminal for analysis through the acquisition and transmission module. This work contributes to a new option for precise monitoring and early diagnosis of CVDs.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Chinese Academy of Medical Sciences

China Postdoctoral Science Foundation

Beijing Municipal Natural Science Foundation

Publisher

Wiley

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