Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

Author:

Fatima Mahak1,Almalki Waleed H.2,Khan Tasneem1,Sahebkar Amirhossein34,Kesharwani Prashant1ORCID

Affiliation:

1. Department of Pharmaceutics School of Pharmaceutical Education and Research Jamia Hamdard New Delhi 110062 India

2. Department of Pharmacology and Toxicology Faculty of Pharmacy Umm Al‐Qura University Makkah 715 Saudi Arabia

3. Biotechnology Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences Mashhad 9177948954 Iran

4. Applied Biomedical Research Center Mashhad University of Medical Sciences Mashhad 9177948564 Iran

Abstract

AbstractThe quest for effective and reliable methods of delivering medications, with the aim of improving delivery of therapeutic agent to the intended location, has presented a demanding yet captivating field in biomedical research. The concept of smart drug delivery systems is an evolving therapeutic approach, serving as a model for directing drugs to specific targets or sites. These systems have been developed to specifically target and regulate the administration of therapeutic substances in a diverse array of chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel diseases, rheumatoid arthritis, and different cancers. Nevertheless, numerous comprehensive clinical trials are still required to ascertain both the immediate and enduring impacts of such nanosystems on human subjects. This review delves into the benefits of different drug delivery vehicles, aiming to enhance comprehension of their applicability in addressing present medical requirements. Additionally, it touches upon the current applications of these stimuli‐reactive nanosystems in biomedicine and outlines future development prospects.

Funder

Indian Council of Medical Research

Publisher

Wiley

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