Affiliation:
1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU‐CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China
2. School of Future Technology University of Chinese Academy of Sciences Beijing 100049 China
3. Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering (IBME) Northwestern Polytechnical University 127 West Youyi Road Xi'an 710072 China
4. Binzhou Institute of Technology Weiqiao‐UCAS Science and Technology Park Binzhou Shandong 256606 China
Abstract
AbstractPyroptosis is increasingly considered a new weathervane in cancer immune therapy. However, triggering specific pyroptotic tumor cell death while preserving normal cells still remains a major challenge. Herein, a brand‐new pyroptosis inducer, copper‐bacteriochlorin nanosheet (Cu‐TBB), is designed. The synthesized Cu‐TBB can be activated to an “on” state in the tumor microenvironment with glutathione (GSH) overexpression, leading to the release of Cu+ and TBB, respectively. Intriguingly, the released Cu+ can drive cascade reactions to produce O2−• and highly toxic ·OH in cells. Additionally, the released TBB can also generate O2−• and 1O2 upon 750 nm laser irradiation. Encouragingly, both Cu+‐driven cascade reactions and photodynamic therapy pathways result in potent pyroptosis along with dendritic cell maturation and T cell priming, thus simultaneously eliminating the primary tumors and inhibiting the distant tumor growth and metastases. Conclusively, the well‐designed Cu‐TBB nanosheet is shown to trigger specific pyroptosis in vitro and in vivo, leading to enhanced tumor immunogenicity and antitumor efficacy while minimizing systemic side effects.
Funder
National Natural Science Foundation of China
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
27 articles.
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