Affiliation:
1. Tianjin Key Laboratory of Drug Delivery & High‐Efficiency School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. China
2. Department of Chemistry and Biochemistry Mendel University in Brno Brno CZ‐61300 Czech Republic
Abstract
AbstractIntestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption, and tight junction (TJ) proteins loss. Excess of H2S in the intestinal milieu produced by the sulfate‐reducing bacteria metabolism contributes to development of IBDs via epithelial barrier breakdown. Conventional interventions, such as surgery and anti‐inflammatory medications, are considered not completely effective because of frequent recurrence and other complications. Herein, a novel oral delivery system, a hydroxypropyl methylcellulose acetate succinate (HPMCAS)‐based polymer‐coated Zr‐based metal–organic framework (UiO‐66) with a Cux‐rhodamine B (CR) probe (hereinafter referred to as HUR), is produced via a co‐flow microfluidic approach with the ability to reduce H2S levels, thus restoring the intestinal lumen milieu. HPMCAS serves as an enteric coating that exposes UiO‐66@CR at the pH of the intestine but not the acidic pH of the stomach. The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration, and TJ proteins upregulation via H2S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. Thus, HUR is verified to be a promising theranostic platform able to decrease the H2S content for intestinal milieu disorder treatment. The presented study therefore opens the door for further exploitation for IBDs therapy.
Funder
Natural Science Foundation of Tianjin City
Young Elite Scientists Sponsorship Program by Tianjin
Subject
Mechanical Engineering,Mechanics of Materials,General Materials Science
Cited by
5 articles.
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