Redox Triggers Guest Release and Uptake Across a Series of Azopyridine‐Based Metal–Organic Capsules

Abstract

AbstractPrecise control over guest release and recapture using external stimuli is a valuable goal, potentially enabling new modes of chemical purification. Including redox moieties within the ligand cores of molecular capsules to trigger the release and uptake of guests has proved effective, but this technique is limited to certain capsules and guests. Herein, the construction of a series of novel metal–organic capsules from ditopic, tritopic, and tetratopic ligands is demonstrated, all of which contain redox‐active azo groups coordinated to FeII centers. Compared to their iminopyridine‐based analogs, this new class of azopyridine‐based capsules possesses larger cavities, capable of encapsulating more voluminous guests. Upon reduction of the capsules, their guests are released and may then be re‐encapsulated when the capsules are regenerated by oxidation. Since the redox centers are on the ligand arms, they are modular and can be attached to a variety of ligand cores to afford varying and predictable architectures. This method thus shows promise as a generalized approach for designing redox‐controlled guest release and uptake systems.