Achieving Ultrasound‐Excited Emission with Organic Mechanoluminescent Materials

Abstract

AbstractUnlike traditional photoluminescence (PL), mechanoluminescence (ML) achieved under mechanical excitation demonstrates unique characteristics such as high penetrability, spatial resolution, and signal‐to‐background ratio (SBR) for bioimaging applications. However, bioimaging with organic mechanoluminescent materials remains challenging because of the shallow penetration depth of ML with short emission wavelengths and the absence of a suitable mechanical force to generate ML in vivo. To resolve these issues, the present paper reports the achievement of ultrasound (US)‐excited fluorescence and phosphorescence from purely organic luminogens for the first time with emission wavelengths extending to the red/NIR region, with the penetrability of the US‐excited emission being considerably higher than that of PL. Consequently, US‐excited subcutaneous phosphorescence imaging can be achieved using a mechanoluminescent‐luminogen‐based capsule device with a quantified intensity of 9.15 ± 1.32 × 104 p s−1 cm−2 sr−1 and an SBR of 24. Moreover, the US‐excited emission can be adequately tuned using the packing modes of the conjugated skeletons, dipole orientation of mechanoluminescent luminogens, and strength and direction of intermolecular interactions. Overall, this study innovatively expands the kind of excitation sources and the emission wavelengths of organic mechanoluminescent materials, paving the way for practical biological applications based on US‐excited emission.